Molecular analysis of chromium and cobalt-related toxicity

Molecular analysis of chromium and cobalt-related toxicity

Occupational and environmental exposure to Co and Cr has been previously linked to a wide array of inflammatory and degenerative conditions and cancer. Recently, significant health concerns have been raised by the high levels of Cr and Co ions and corrosion products released by biomedical implants. Herein, we set to analyze the biological responses associated with Co and Cr toxicity. Histologic...

[Molecular mechanism involved in chromium(VI) toxicity].

Chromium exists in many different oxidation states in the environment, Cr(VI) and Cr(III) being the most stable forms. Chromium has been known for over 100 years to be a human carcinogen. The greatest risk of cancer from chromium exposure is associated with Cr(VI). Cr(VI) enters cells via the sulfate anion transporter system and is reduced to intermediate oxidation states, such as Cr(V) and Cr(...

Effect of particulate cobalt, chromium and cobalt-chromium alloy on human osteoblast-like cells in vitro.

Shear Bond Strength of Porcelain Veneering to Nickel-Chromium, Chromium-Cobalt, Zirconia and Lithium Disilicate

Background and Aim: High chipping rates of the veneering porcelain in zirconia ce-ramic restorations have been reported in many clinical studies. However, information on the bonding behavior of veneering porcelain to zirconia and lithium disilicate frameworks is limited. The purpose of this study was to evaluate the bond-ing strength of porcelain veneering to zirconia, lithium disilicate, nicke...

Metal release from hip prostheses: cobalt and chromium toxicity and the role of the clinical laboratory.

Individuals with advanced hip disease suffer from pain, impaired hip function, and decreased quality of life. Roughly one million metal-on-metal (MoM) hip prostheses have been implanted worldwide in order to ameliorate these issues. While most MoM hip replacements are successful, some patients suffer from serious adverse effects secondary to the release of metal debris due to implant wear and c...